MFS Fertility Blog

Using Serophene to Enhance Male Fertility and Increase Sperm Count

Posted on July 17, 2013 in Male Infertility

Serophene (also prescribed under the brand name Clomid or its generic name clomiphene citrate) is most commonly used as a female fertility drug, but it also effectively stimulates sperm production in men with low sperm count.

How does Serophene enhance male fertility?
Serophene stimulates the brain to produce two hormones that are necessary for the production of sperm and testosterone by the testes. Adequate levels of these hormones (follicle stimulating hormone or FSH and luteinizing hormone or LH) can enhance both sperm count and semen quality.

Who can benefit from Serophene treatment?
Serophene may be used to increase sperm count in men whose infertility is based on low testosterone levels. Because Serophene works by signaling the testes to produce testosterone, its success depends on the ability of the testes to make testosterone. Your urologist must first confirm that the underlying cause of your low sperm count is not due to a problem within the testes, such as a blockage, varioceles, or testicular cancer.

How is Serophene administered?
Serophene is an oral pill that is taken daily at a typical starting dose of 25 mg. Your doctor will regularly monitor your hormone levels to ensure they stay within limits, as too much testosterone can negatively impact your sperm count. Normal testosterone levels are typically achieved in 4-6 weeks; however, it can take 3-6 months before sperm production is enhanced. Regular semen analyses will also be required during this time. Once normal sperm production is achieved, Serophene treatment may be discontinued.

What are the side effects of Serophene?
Some men have had allergic reactions to Serophene, including difficulty breathing, hives, and swelling of the throat, tongue, lips, and face. Other side effects can include blurred vision, weight gain, headache, changes in mood, and in some cases, breast enlargement.

Talk with your urologist today to find out if Serophene might be a treatment option for you.

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